Platycodon root mitochondrial biogenesis

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WebbPlatycodin D Protects Human Fibroblast Cells from Premature Senescence Induced by H2O2 through Improving Mitochondrial Biogenesis These results indicated that PLD … Webb10 apr. 2024 · The frequency of RNA editing was measured for each editing site in the 31 mitochondrial PCGs in three tissues including leaf, root, and stem. The average editing frequency of non-synonymous changes was significantly higher than those of synonymous changes (one-sample Student’s t-test, p-values ≤ 0.05) in the root, leaf and stem.

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Webb9 jan. 2024 · Mitochondria consist of four compartments: outer membrane (OM), intermembrane space (IMS), inner membrane (IM) and matrix. A large variety of functions have been assigned to mitochondrial proteins ... WebbMitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy. Mitochondrial-mediated oxidative stress in response to high glucose is … marriott westin boston waterfront

Nutrients Free Full-Text Platycodon grandiflorus Root Extract ...

WebbMitochondrial biogenesis can be disrupted in hypoxia. Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1α) is a core factor required for mitochondrial biogenesis. Cementoblasts are root surface lining cells that play an integral role in cementum formation. Webb7 feb. 2003 · PGC-1α stimulates expression of nuclear respiratory factor 1 (NRF-1) and mitochondrial transcription factor A (mtTFA), initiating the expression of nuclear and mitochondrial genes that encode mitochondrial proteins ( 6, 7, 9 ). Webb13 jan. 2024 · A number of mitochondria-associated proteins that are involved in root growth and its regulation have been described. For example, AtPHB3 is a conserved mitochondrial type I prohibitin, which is reported to maintain the mitochondrial morphology and cell division in the root meristem of Arabidopsis [].This finding also provides … marriott westin crystal city

Targeting Mitochondrial Biogenesis with Polyphenol Compounds

Mitochondrial biogenesis - Wikipedia

Webb1 feb. 2024 · Interestingly, several studies have reported that Platycodon grandiflorum root extract (PGE), besides exhibiting other bioactive effects, displays neuroprotective, anti … Webb2 maj 2024 · Mitochondria are dynamic organelles that orchestrate a number of fundamental metabolic and signaling processes, producing most of the cellular energy via oxidative phosphorylation. HSCs have a relatively high amount of mitochondria that are mostly inactive. marriott west hotel waukesha wiWebbMitochondrial homeostasis ( Figure 1 ), which occurs through the balance of biogenesis, fission/fusion events, and autophagic degradation of dysfunctional mitochondria, is essential to maintain tissue energetics and to prevent chronic oxidative stress ( 40, 41 ). marriott westin excelsior rome

"Webb1 maj 2012 · Platycodon grandiflorum root attenuates vascular endothelial cell injury by oxidized low-density lipoprotein and prevents high-fat diet-induced dyslipidemia in mice … " - Platycodon root mitochondrial biogenesis

Platycodon root mitochondrial biogenesis

Peanut AhmTERF1 Regulates Root Growth by Modulating Mitochondrial …

WebbPlatycodin D Protects Human Fibroblast Cells from Premature Senescence Induced by H2O2 through Improving Mitochondrial Biogenesis These results indicated that PLD prevented H2O2-induced premature senescence in vitro by improving mitochondrial biogenesis to attenuate age-dependent endogenous oxidative damage. Webb10 aug. 2015 · Our work reveals a key regulatory mechanism that couples mitochondrial biogenesis with mitophagy to regulate energy metabolism in C. elegans. The nematode NRF2/NFE2L2 homolog, SKN-1, is a nodal ...

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Webb29 sep. 2024 · We used dimethyl-fumarate (DMF) and pioglitazone (pio) as agents activating NRF2 and PPAR-γ, respectively, and two synthetic hybrids acting differently on the NRF2/ARE pathway. Only DMF and compound 1 caused early effects on the mitochondria. Both DMF and pio induced mitochondrial biogenesis but different … Webb18 feb. 2024 · Here, we identify the transcription factors KLF2 and ETV1 as transcriptional repressors of mitochondrial biogenesis. The up-regulation of these two proteins in patient cells and mouse tissues of two lysosomal diseases, Niemann-Pick type C and ASM deficiency, underlies the mitochondrial defects observed in these syndromes.

WebbMitochondrial-mediated oxidative stress in response to high glucose is proposed as a primary cause of dorsal root ganglia (DRG) neuron injury in the pathogenesis of diabetic neuropathy. In the present study, we report a greater number of mitochondria in both myelinated and unmyelinated dorsal root a … Webb10 apr. 2024 · Reactive oxygen species (ROS) promote oxidative stress, which directly causes molecular damage and disrupts cellular homeostasis, leading to skin aging. Baicalein, a flavonoid compound isolated from the root of Scutellaria baicalensis Georgi has antioxidant, anticancer, anti-inflammatory, and other medicinal properties. We aimed …

Webb23 juli 2024 · Mitochondrial biogenesis is the cellular process that produces new mitochondria. But mitochondria cannot be produced from scratch ( de novo ); new mitochondria are produced by adding new … Webb31 jan. 2024 · Background: Although Platycodin D (PLD) is the main active saponin of Platycodon grandiflorum (PG) and responsible for multiple therapeutic benefits, …

Webb1 mars 2024 · The mitochondrial DNA (mtDNA) copy number was calculated using a mitochondrial gene, cytochrome b (Cytb), normalized against a nuclear gene, Rpph1 ( …

Webb22 okt. 2024 · While mitochondrial biogenesis increases the number and content of the organelles in a coordinated effort with the nucleus , mitochondrial dynamics drives the formation of larger or smaller organelles through the antagonist activities of fusion and fission . Mitochondria are recently recognized by their dynamic nature. marriott westin galleria houston txWebb5 maj 2024 · Mitochondrial calcium uniporter (MCU) has an important role in regulating mitochondrial calcium (Ca 2+) homeostasis.Dysregulation of mitochondrial Ca 2+ homeostasis has been implicated in various cancers. However, it remains unclear whether MCU regulates mitochondrial Ca 2+ uptake to promote cell growth in colorectal cancer … marriott westin grand caymanWebbThe biogenesis of mitochondria is extremely plastic in response to environmental stimuli, developmental signals, and cellular energy demand [ 7] and requires mitochondrial DNA (mtDNA) replication, synchronous production of mitochondrial and nuclear proteins, and localization of nuclear-encoded proteins and phospholipids in different … marriott westin fort lauderdale beach resortWebb23 juli 2024 · Platycodon grandiflorus (Jacq.) A.DC. (PG) has long been used as an ingredient of foods and is known to have beneficial effects on cognitive functions as … marriott westin lagunamarWebbNearly half a century has passed since the discovery of cytoplasmic inheritance of human chloramphenicol resistance. The inheritance was then revealed to take place maternally by mitochondrial DNA (mtDNA). Later, a number of mutations in mtDNA were identified as a cause of severe inheritable metabolic diseases with neurological manifestation, and the … marriott westin copley place bostonWebb30 aug. 2016 · The Platycodon grandiflorusroot, a Korean medicinal food, is well known to have beneficial effects on obesity and diabetes. In this study, we demonstrated the … marriott westin hamburgWebbResults: Mitochondrial biogenesis is a product of complex interactions between the nuclear and mitochondrial genomes. Signaling pathways, such as those activated by … marriott westin gaslamp quarter