WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation … WebSep 2, 2024 · Melatonin alleviates renal dysfunction in sepsis-induced acute kidney injury. 8-week-old mice were treated with melatonin (25 μg/ml) dissolved in drinking water for 14 days. ... Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury in Rats via Induction of Anti-Aging Protein, Klotho. Food Chem. Toxicol. 129, 201–210. …
Exploring the Metabolic Differences between Cisplatin- and UV …
WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … did johnny gosch have siblings
Pro-Inflammatory Signalling PRRopels Cisplatin-Induced Toxicity
WebCisplatin-induced AKI typically occurs 5–7 days after therapy, whereas dialysis-requiring AKI is uncommon in the absence of concomitant nephrotoxic exposures. AKI typically resolves within a few weeks, but progressive CKD … WebThe results suggest that the plant extract (250 and 500 mg/kg) was effective in significantly altering the indices of cisplatin induced dysfunction of renal proximal tubule cells under … WebJan 18, 2024 · Background Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI. Methods Japanese patients, who received cisplatin as the first-line chemotherapy at … did johnny mathis have children