Cisplatin coordination complex

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August undefined, 2024

WebAug 15, 2024 · In simple terms, the coordination number of a complex is influenced by the relative sizes of the metal ion and the ligands and by electronic factors, such as charge which is dependent on the electronic configuration of the metal ion. Introduction WebCancer continues to be responsible for the deaths of more than 9 million people worldwide each year. Current treatment options are diverse, but low success rates, particularly for those with late-stage cancers, continue to be a problem for clinicians and their patients. The effort by researchers globally to find alternative treatment options is ongoing. In the …

Tetrahedral vs. Square Planar Complexes - Chemistry LibreTexts

WebJun 19, 2024 · Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(η6-p-cymene)4Ru4(C6H2O4)2(2)2](CF3SO3)4 … WebCisplatin, a platinum analogue, is an alkylating agent used in combination with other agents to treat a variety of solid malignancies, including lung cancer, head and neck cancer, mesothelioma, ovarian cancer, and bladder cancer. It is also used prior to bone marrow and stem cell transplantation. graf shirts

Cisplatin - Sigma-Aldrich

WebCisplatin coordinates to DNA mainly through certain nitrogen atoms of the DNA base pairs; these nitrogen atoms (specifically, the N7 atoms of purines) are free to … WebSep 18, 2024 · National Center for Biotechnology Information WebMay 10, 2024 · Notable examples include the anticancer drugs cisplatin ( PtCl 2 ( NH 3) 2 ). A square planar complex also has a coordination number of 4. The structure of the complex differs from tetrahedral because the ligands form a simple square on the x and y axes. Because of this, the crystal field splitting is also different (Figure 1 ). china buzz lightyear

22.4: Coordination Compounds - Chemistry LibreTexts

Platinum Coordination Complexes - PubMed

WebSep 15, 2024 · Cisplatin (cisplatin injection) (cis-diamminedichloroplatinum) is a heavy metal complex containing a central atom of platinum surrounded by two chloride atoms … WebOccasionally a 4-co-ordinated complex turns out to be square planar. There's no easy way of predicting that this is going to happen. The only one you might possibly come across at this level is cisplatin which is used … chinabyte.comWebStimulated by the enormous success of the inorganic complex cisplatin in tumor treatment, interest in metal complexes has recently grown. Within cells, metal complexes can participate in reactions that are not possible with conventional organic substances, and most of them have promising efficacy as anticancer drugs. china byd public stock

"WebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. … " - Cisplatin coordination complex

Cisplatin coordination complex

Platinum coordination complexes which circumvent …

WebAbstract We report the synthesis and comprehensive characterization of a new platinum-AIEgen coordination complex. Possessing a high 1 O 2 quantum yield of 0.75 in water, the complex efficiently kills cisplatin-resistant cancer cells under mild white light irradiation. WebCisplatin or (SP-4-2)-diamminedichloridoplatinum(II) is one of the most potential and widely used drugs for the treatment of various solid cancers such as testicular, ovarian, head and neck, bladder, lung, cervical cancer, melanoma, lymphomas and several others. Cisplatin exerts anticancer activity … Cisplatin: The first metal based anticancer drug

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WebIn coordination complexes between an electropositive transition metal atom and an electronegative ligand, the transition metal is approximately in an ionic state as assumed in crystal field theory, so that the electron configuration and d electron count are those of the transition metal ion rather than the neutral atom. WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of …

WebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity … WebThe platinum coordination complex cisplatin, or cis -diamminedichloroplatinum (II) (see Figure 1 ), functions as a cytotoxic anticancer chemotherapy agent and shows a remarkable degree of selectivity in destroying testicular cancer cells.

WebCisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to bind to a guanine base on DNA. This property is … WebConsidering the strong coordination capacity of copper, a variety of organic ligands, especially carboxyl-modified organic ligands, can be used to synthesize Cu-MOF through coordination reaction with copper. ... Copper complexes as anticancer agents. Cisplatin is a milestone in the field of metal complexes for cancer treatment, but because of ...

WebJul 4, 2024 · Coordination numbers of two and three are common for d 10 metal ions. Tetrahedral and square planar complexes have a coordination number of four; trigonal …

WebSep 12, 2024 · The platinum coordination complexes are a group of antineoplastic agents that are usually classified as alkylating agents, but which have distinctive features. Their anticancer activity appears to relate to the cross linking of DNA molecules in a fashion similar to standard alkylating agents. graf shipping hullWebMar 29, 2024 · Reviewed on 3/29/2024. Cisplatin: An anticancer drug that belongs to the family of drugs called platinum compounds. Cisplatin is used in the treatment of a wide … china by numbers cgtnWebPlatinum coordination complexes which circumvent cisplatin resistance Platinum coordination complexes which circumvent cisplatin resistance Authors K R Harrap 1 , … china by denbyWebSep 5, 2015 · Taken together, the complex has been shown to be a potential DNA damaging agent and, in the light of the superiority of the complex over cisplatin, we are further investigating the possibility of targeted nano-delivery of … china by johann haviland bavaria germanyWebJul 19, 2024 · Cisplatin and drug design 16–18 years Resource RSC Education Assess learners’ understanding of the mechanism of cisplatin as an anticancer drug with these examination-style questions. graf septic tank installationWebMethods: The contribution of aliphatic acyclic, aliphatic cyclic, and aromatic diamine ligands to the anticancer activity and selectivity/toxicity of metal complexes with different metal ions were analyzed by comparison with organic ligand alone and/or conventional platinum-based chemotherapeutics. china by kids learning tubeWebCisplatin was the first platinum complex to be used clinically but is being replaced by carboplatin. Cisplatin can cause typical type A ADRs such as marrow depression and … graf ship nordhorn