WebMay 15, 2014 · In contrast, at the high levels of FGF2, pERK levels peak before 5 minutes and decrease to low levels within 20-30 minutes. Therefore the dose response curve at time points later than 10 minutes shows a strong biphasic response (Figure 2C). Thus, the reduced model adequately captures all of the essential features of pERK dynamics in … WebFeb 25, 2024 · In line with the biphasic cytokine response we noted from the whole cortex after injury, microglia showed upregulation of cGAS at 24 h post-injury and a trending increase of STING at 2- and 24 h after CCI (Supplementary Figures 5A,B). Non-adherent cells (CNS cells remaining after the removal of microglia) did not show increased …
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WebFeb 7, 2024 · An idealized biphasic dose–response curve (Arndt-Schulz curve) in the PBM study. Dose: in the first case, irradiation time ... was used to treat human epidermal equivalent (HEES) in the presence of OA. Figure 5 shows that all three groups can inhibit inflammation, and the effect of 0.2 J/cm 2 and 1.2 J/cm 2 is better than that of 0.5 J/cm 2. WebMar 1, 2024 · In many scientific disciplines, recognition of hormesis as a significant phenomenon is now the rule rather than the exception [1, 2, 3].To recognize those cases where hormesis really exists and to adequately establish the significance of this biphasic dose–response phenomenon [4], the generation and statistical modelling of a complete … incluso gmbh
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